|Appearance||Lyophilized White Powder|
|Synonyms||Acetyl Glutamyl Heptapeptide-3|
|Storage||Snap-8 is stable at room temperature for 90 days, It should be stored in a freezer for any extended period of time.|
Molecular formula: C41H70N16O16S
Molecular weight: 1075.16
SNAP-8 is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex,thereby modulating its formation. If the SNARE complex is slightly destabilized, the vesicle can not release neurotransmitters efficiently andtherefore muscle contraction is attenuated, preventing the formation of linesand wrinkles
- Reduces the depth of wrinkles on the face caused by the contraction of muscles of facial expression, especially in the foreheadand around the eyes.
- A safer, cheaper, and milder alternative to Botulinum Toxin, topically targeting the same wrinkle-formation mechanism in avery different way.
- Has been incorporated in cosmetic formulations such as emulsions, gels, sera, etc., where removal of the deep lines or wrinkles inthe forehead or around the eyes area is desired.
INCI name: Water, Acetyl Glutamyl Heptapeptide-1
Appearance: Transparent solution
Contents: 0.05 % SNAP-8 Powder
Preservative: 0.3 % Phenonip
The synthesis of SNAP-8 involves a final freeze-dryingstep. Freeze-dried products are commonly obtained as a polymorphous crystallinepowder, which means that locally some aggregates and differences in crystalsize may appear. This polymorphism is not associated to chemical differencesand extensive work performed by the analytical department has ensured the homogeneity of the product. SNAP-8 is presented either as SNAP-8 Powder, anoctapeptide in powder form which can be easily dissolved in water, or as SNAP-8Solution, an aqueous solution containing 0.5 g/L of the powder version. It can be incorporatedat the final stage of the manufacturing product, provided the temperature is below 40 degrees Celsius. Taking intoconsideration the concentration of peptide in SNAP-8 Solution, it is recommended that 3 to 10% of the solution is present in the finalformulation in order to obtain significant anti-wrinkle activity.
SNAP-8 Powder and SNAP-8 Solution must be kept in a cool, dark and clean place toensure a shelf life of at least twelve months. For long term storage it is recommended to store bothforms at 4 ºC which extends shelf life to at least eighteen months. In rarecases, refrigerated storage of SNAP-8 Solution can cause precipitationof the preservative. This does not affect the integrity of the product.