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position:Home > Product > Pharmaceuticals Chemicals

Pharmaceuticals Chemicals

Anastrozole(Arimidex)

Anastrozole(Arimidex)
  • Details:
    CAS No:120511-73-1

    Molecular formula:120511-73-1

    Molecular weight:293.37

    Appearance:White powder.

    Assay:99%

    Delivery time:2-3 business days door-to-door

    Minimum order:50g

    Supply ability:40kg/month

    Quality standard:USP30

Detailed

Anastrozole is an aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for

metastasis in both pre and postmenopausal women. The severity of breast cancer is increased by estrogen, as sexhormones cause hyperplasia, and differentiation at estrogen receptor sites. Anastrozole works by inhibiting the synthesis of estrogen.

The trial suggested that anastrozole is the preferred medical therapy for Postmenopausal women with localized breast cancer that is estrogen receptor (ER) positive.

Three azole potent selective aromatase inhibitors, which inhibit rely on aromatase cytochrome P -450 to block 

estrogen biosynthesis, and the main factors of estrogen to stimulate breast cancer cell growth. It can treat breast  cancer, especially suitable for those who relapse after treatment with hormone auxiliary advanced breast cancer after menopause women.

Below is the test results of Anastrozole:

Items

Standard

Results

Description

White crystalline powder

Complies

Identification

IR
HPLC
Reactive

Conform with standard IR
Conform with standard HPLC
Conform

Solubility

Freely soluble in methanol, acetone, ethanol and tetrahydrofuran. And very soluble in acetonitrile

Complies

Total Impurity

max.0.5%

0.18%

Total Unspecified Impurity

max. 0.2%

0.08%

Individual unspecified impurlty

max. 0.1%

0.05%

Related compound B

max. 0.2%

0.07%

Related compound C

max. 0.2%

0.04%

Related compound D

max. 0.1%

0.05%

Related compound E

max. 0.1%

0.06%

Limit of cyclohexane

max. 0.08%

ND

Limit of ethylacetate

max. 0.1%

0.07%

Melting point

81.0~84.0

82.5~83.2

Water

max. 0.3%

0.21%

Residue on ignition

max. 0.1%

0.07%

Heavy Metals

max.0.001%

Complies

Assay(HPLC)

98.0%~102.0%

99.8%

Storage

Cool and dry



Hits:  UpdateTime:2016-12-05 10:35:55  【Printing】  【Close】
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